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pentobarbital will lower the level or result of pioglitazone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.pentobarbital improves effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Warning/Keep an eye on. Coadministration of ifosfamide with CYP2B6 inducers could improve metabolism